Saxsons Group

Radiopharmacist's Notes · CRP™ Dispensing System

Three layers of responsibility — and the line between them.

A CRP + FLEX cyclotron dispensing workflow is three stacked layers: the host hot cell that owns the shielding and the GMP environment, the CRP automation that owns the dispensing mechanics, and the radiopharmacy programme that owns the recipes, the QC release and the AERB licence. Each layer is necessary; none of them is sufficient on its own. This page draws the line.

Who owns what

Three layers, three different sources. The middle layer (CRP) is what we sell; the outer two are needed to make a working radiopharmacy around it.

Host hot cell (typically FLEX)

  • 100 mm Pb shielding (India config)
  • Grade A clean-air environment per EU GMP Annex 1
  • Air-tight pass-through for radio-fluids and gases
  • AERB site-licence physical-shielding compliance
  • Vial extraction system for shielded container retrieval

Source: FLEX product page; AERB cyclotron-facility 2017.

CRP — this page

CRP automation module

  • Automated dispensing of open and closed vials under sterile conditions
  • Volume / weight deviation guaranteed under 1%
  • Crimped aluminum-ring and push-fit cap handling (Compact plus)
  • Septum-piercing for closed-vial dispensing (Compact + option)
  • Hands-out-of-cell workflow — operator interacts via control PC

Source: CRP product page.

Radiopharmacy programme (you)

  • Site-wide Contamination Control Strategy (CCS) under Annex 1
  • Dispensing recipes + calibration cross-checks
  • QC release (radiochemical purity, sterility, endotoxin)
  • Batch records + Annex 11 audit trail for every dispense
  • AERB site licence under Atomic Energy (Radiation Protection) Rules 2004

Source: EU GMP Annex 1 (rev. 2022); Annex 11; AERB 2017 Regulatory Requirements.

Why this scoping matters at procurement

A buyer evaluating CRP without the host-cell context will under-spec — assume CRP comes with shielding, or with an AERB licence, or with a calibration chain. It doesn\'t. CRP is the precision dispensing layer; everything around it has to be specified separately.

The Saxsons-supplied Indian package is CRP plus the FLEX host cell plus the AERB import documentation. That\'s what makes the three-layer model add up to a working dispensing bench.

Sources: CRP + FLEX product pages; AERB 2017 Regulatory Requirements; EU GMP Annex 1 (rev. 2022).

Scope of this page

The three-layer split is a buyer-procurement model, not a regulatory taxonomy. The FLEX page provides the full GMP stack mapping (Annex 3 + Annex 1 + Annex 11 + AERB). This page just sets the procurement boundary so the CRP buy is correctly scoped.

Sources cited on this page

  • the manufacturer. CRP Radiopharmaceutical Dispensing System. Manufacturer product page. temasinergie.com ↗
  • the manufacturer. FLEX — GMP Grade A shielded dispensing isolator. Manufacturer product page. temasinergie.com ↗
  • European Commission. EudraLex Vol. 4 Annex 1 — Manufacture of Sterile Medicinal Products. Revised text, fully effective 2023-08-25. EC text ↗
  • Atomic Energy Regulatory Board (India). Regulatory Requirements and Guidelines for Medical Cyclotron Facility. AERB, 2017. AERB PDF ↗