Authorised Indian Distributor
Saxsons Group
New Delhi, India · Since 1997
O-18 Enriched WaterCyclotron-Grade [18O]H₂O — 98–99 % Atom O-18 for F-18 Target Loading
Cyclotron-grade [18O]H₂O target water for F-18 production via the ¹⁸O(p,n)¹⁸F reaction. Isotopic enrichment 98–99 % atom O-18, chemical purity > 99.99 %, conductivity < 3.0 µS/cm, sterile and pyrogen-free (< 0.25 EU/mL), pH 6.0–8.0. Supplied in sealed crimp-cap glass vials with chlorobutyl rubber septum, sterilised prior to filling. Per-batch certificate of analysis covering isotopic, chemical, sterility and ionic-impurity testing. Cold-chain delivery across India.
Key Features
- High-enrichment cyclotron-grade [18O]H₂O for F-18 production via the ¹⁸O(p,n)¹⁸F nuclear reaction
- Isotopic enrichment 98–99 % atom O-18 (residual O-17 < 3 %, O-16 < 3 %) — higher than the 95–97 % entry-grade water
- Chemical purity > 99.99 % m/m — controlled at the manufacturer with normalisation against hydrogen isotope distribution
- Electrical conductivity < 3.0 µS/cm — confirms the absence of ionic impurities that would poison the cyclotron target
- Sterile (per-batch sterility-test certified) and pyrogen-free at < 0.25 EU/mL (Limulus Amebocyte Lysate / LAL)
All Features
- High-enrichment cyclotron-grade [18O]H₂O for F-18 production via the ¹⁸O(p,n)¹⁸F nuclear reaction
- Isotopic enrichment 98–99 % atom O-18 (residual O-17 < 3 %, O-16 < 3 %) — higher than the 95–97 % entry-grade water
- Chemical purity > 99.99 % m/m — controlled at the manufacturer with normalisation against hydrogen isotope distribution
- Electrical conductivity < 3.0 µS/cm — confirms the absence of ionic impurities that would poison the cyclotron target
- Sterile (per-batch sterility-test certified) and pyrogen-free at < 0.25 EU/mL (Limulus Amebocyte Lysate / LAL)
- pH 6.0–8.0 neutral physiological range; protects target body and ion-exchange recovery columns
- Total organic carbon (TOC) < 2.0 mg/L; halides, alkali / alkaline-earth metals, transition metals and anions all certified ND (below detection)
- Sealed crimp-cap glass vials with chlorobutyl rubber septum; bottles sterilised prior to filling; tamper-evident seal
- Standard 50 g / vial fill (other fill sizes by lot agreement) — single-shot target loading or multi-shot draw via dispensing needle
- Per-batch certificate of analysis covering isotopic composition, chemical purity, sterility, pyrogen, pH and ionic-impurity panel
- Cold-chain delivery across India under AERB / CDSCO import paperwork; transport logger packed with each lot
- Documentation: per-lot CoA, batch sterilisation record, AERB import licence pack
Technical Specifications
| Isotopic composition | O-18 ≥ 98 % atom (typical 98.5–99.0 %); O-17 < 3.0 % atom; O-16 < 3.0 % atom |
| Chemical purity | > 99.99 % m/m; normalised with respect to hydrogen isotope distribution |
| Electrical conductivity | < 3.0 µS/cm |
| pH | 6.0–8.0 |
| Total organic carbon | < 2.0 mg/L (typical < 1.0 mg/L) |
| Pyrogen (LAL) | < 0.25 EU/mL |
| Sterility | Per-batch sterility-tested; sealed bottles sterilised prior to filling |
| Halide panel | F⁻, Cl⁻, Br⁻, I⁻ all ND (each < 0.1 mg/L) |
| Metal panel | Ca, Mg, Na, K, Cu, Fe, Zn all ND (each per panel limit, typically < 0.05 mg/L) |
| Anion panel | PO₄³⁻, NO₃⁻, SO₄²⁻, NH₄⁺ all ND |
| Packaging | Glass vial with chlorobutyl rubber septum, crimp-sealed; 50 g / vial typical (other fills by lot agreement) |
| Shelf life | Typically 24 months from manufacture under specified storage |
| Compliance framework | AERB cyclotron-facility consumable; CDSCO import licence; per-lot CoA |
Applications
The cyclotron consumable that gates every F-18 batch downstream
[18F]FDG production
The default target water for [18F]FDG synthesis — the F-18 from 98–99 % O-18 water feeds the FDG synthesis module with the activity profile FDG-grade kits expect. Higher enrichment means higher per-shot F-18 activity for the same beam time.
[18F]NaF skeletal imaging
F-18 production for [18F]NaF skeletal-imaging tracer. NaF formulation is a downstream radiochemistry step from the same target water — same isotopic spec, same vial spec.
[18F]PSMA + neuro tracers
F-18 production for emerging clinical tracers — [18F]PSMA-1007, [18F]Flutemetamol, [18F]Florbetapir and [18F]choline. High-enrichment target water gives sharper per-shot activity for the small-volume target-loading workflow these tracers use.
Investigator-initiated F-18 work
IIP F-18 labelling and method-development workflows — same target water, same isotopic spec. The CoA serves as the input-material qualification record for the investigator protocol.
O-18 water recovery + recycling
After F-18 elution, the post-irradiation target water can be ion-exchanged + concentrated for re-use. Higher-enrichment input water means higher-enrichment recovered water — supports closed-loop O-18 water economics for high-volume sites.
Cyclotron target validation
On a new target body or after a target rebuild, the target validation run uses certified-spec water — eliminates the input-material variable when characterising target performance.
Why O-18 Enriched Water?
The 18O(p,n)18F cross section scales with the O-18 atom fraction. Moving from 95–97 % entry-grade water to 98–99 % cyclotron-grade gives a measurable per-shot activity boost — same beam time, more F-18 at end-of-bombardment, more patient doses per batch.
Ionic impurities in target water co-irradiate with the O-18 and produce parasitic radionuclides (Na-22 from Na, Co-58 from target-body contact). The < 3.0 µS/cm conductivity spec gates the input material below the threshold where these by-products show up on the QC gamma spectrum.
Per-batch certificate of analysis is the input-material qualification record for the cyclotron GMP file. AERB inspection of a PET radiopharmacy reads the CoA chain; cold-chain delivery preserves the chain from manufacture to target loading.
Catalogs & Resources
IAEA + AERB references that anchor cyclotron target-material qualification. Contact Saxsons for India pricing, per-lot CoA review and cold-chain delivery scheduling.
IAEA TRS 471 — Cyclotron Produced Radionuclides
IAEA technical report on cyclotron-produced radionuclides including target-material specifications and F-18 production chemistry.
IAEA TRS 466 — Quality Assurance for PET and PET/CT Systems
IAEA technical report covering PET radiopharmacy QC including input-material qualification expectations.
AERB — Safety Code for Medical Cyclotron Facility
Indian regulatory framework for medical cyclotron facility licensing including consumable qualification expectations.
O-18 Enriched Water
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FAQ
O-18 enriched target water — questions we hear from Indian cyclotron teams
What O-18 water is and why F-18 production depends on it, why 98-99 % atom O-18 rather than lower enrichment, what the CoA and cold-chain deliver for the GMP file, and O-18 water recovery service.
Q.What is O-18 enriched water and why does a PET cyclotron need it?
O-18 enriched water ([18O]H₂O) is water where the oxygen atoms have been chemically enriched from natural-abundance ~0.2 % O-18 to 98–99 % O-18. It is the target material for F-18 production — the cyclotron beam hits the O-18 water target, the (p,n) nuclear reaction converts O-18 to F-18, and the enriched water solution now carrying the F-18 activity leaves the target for the synthesis chemistry. Without high-atom-percent O-18 water, F-18 yield drops sharply and per-patient F-18 cost becomes uneconomic.
Q.Why 98–99 % atom O-18 rather than lower enrichment?
F-18 production yield scales with O-18 atom fraction — using 90 % atom O-18 water instead of 98 % cuts the F-18 activity per target load by roughly 8 %. Over a year of production at a busy PET centre, that difference is thousands of GBq of missed F-18 activity and hundreds of patients that could not be scheduled. Higher atom percent is more expensive per gram but pays back through the higher F-18 yield per beam-hour.
Q.How is the water supplied and quality-checked before target loading?
Each lot ships with a Certificate of Analysis documenting atom percent O-18, chemical purity, sterility and any trace-contaminant analysis. Cold-chain delivery preserves the material from manufacture to target loading. The radiopharmacy verifies the CoA before loading the target — that CoA becomes the input-material qualification record for the cyclotron GMP file that AERB inspection reads.
Q.What is the shelf life and storage requirement?
O-18 enriched water is chemically stable at room temperature; the shelf-life is set by the sterility qualification of the vial rather than by chemical degradation. Typical shelf life is 12–24 months depending on the vial format; the CoA specifies the exact expiry for each lot. Recovered / recycled O-18 water (the un-reacted majority of the target loading) can be re-purified and re-used through the manufacturer's recovery service — significantly reduces per-batch running cost for high-throughput centres.
Q.How is O-18 water supplied and licensed in India?
Distributed across India by Saxsons Group. Supply covers scheduled-date delivery against the department's cyclotron production calendar, cold-chain logistics, per-lot Certificate of Analysis, batch sterilisation record and AERB import licence pack. Saxsons has coordinated O-18 water supply for the Indian PET cyclotron network.
O-18 Enriched Water supplier in India — Saxsons Group
Saxsons Group has supplied cyclotron equipment to over 1,000 Indian hospitals since 1988. Every consignment of O-18 Enriched Water ships with cold-chain logistics, AERB import documentation, CDSCO registration references and a Certificate of Analysis delivered before dispatch — the paperwork your radiation-safety and procurement teams need, pre-assembled.
- Nationwide delivery footprint — every metro and tier-2 city in India, scheduled to your treatment / procedure calendar.
- AERB & CDSCO documentation — import licence, radiation-safety paperwork and RSO briefing pre-assembled for the audit file.
- 40+ years in Indian oncology — long-standing supply relationships with AIIMS, Tata Memorial, and hundreds of tertiary-care centres.
- Single point of accountability — one purchase order, one delivery contact, one after-sales team across the whole product family.
Also supplied by Saxsons Group across India
The 98–99 % cyclotron-grade O-18 water for the F-18 production line
Contact Saxsons Group for O-18 enriched water supply, per-lot CoA review, AERB / CDSCO import paperwork and cold-chain delivery scheduling across India.