Intracranial SRS — single-iso multi-met, frame-vs-frameless, rotational-correction studies. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Diffusion tensor imaging (DTI) has increasingly been incorporated into stereotactic radiosurgery (SRS) to improve visualization of eloquent neural pathways and to evaluate treatment-related microstructural changes. However, its roles in tractography-guided treatment planning, dosimetric optimization, clinical outcomes, and prognostication have not been systematically characteri…
James K. Liu, Ahmed Sabra, Yaxel Levin-Carrion, Caryn J. Ha et al.
Abstract Introduction Planned subtotal resection (STR) of vestibular schwannomas (VS) followed by stereotactic radiosurgery (SRS) has gained popularity for minimizing facial nerve injury. However, recurrence risk correlates with residual tumor volume, and long-term outcomes remain unknown. The authors report their facial nerve outcomes with planned maximal safe resection using …
Angel Bueno, Antonio Dono, Oscar Alcantar, Christian Amezquita-Contreras et al.
BACKGROUND: Glioblastoma isocitrate dehydrogenase (IDH)-wildtype (GBM) has been reclassified based on molecular and phenotypic features. Intratumoral hemorrhage is a phenotypic subtype with poorly understood molecular and clinical characteristics. We aimed to characterize the molecular profile and outcomes of hemorrhagic glioblastoma (hGBM) compared with non-hGBM. METHODS: A re…
Ryuichi Noda, Atsuya Akabane, Mariko Kawashima, Masafumi Segawa et al.
Brain metastases from non-small cell lung cancer are typically managed with local therapies, such as surgery and radiotherapy, whereas systemic treatments have historically demonstrated limited efficacy in the intracranial setting. Immune checkpoint inhibitors, particularly programmed cell death-1 inhibitors, have recently demonstrated potential in this context. We report a cas…
Diffuse intracranial dural arteriovenous fistulas involving interconnected dural sinuses are uncommon lesions with complex angioarchitecture and an evolving clinical course. However, long-term treatment outcomes and surveillance strategies remain poorly characterized. We retrospectively reviewed 49 consecutive patients with intracranial dural arteriovenous fistulas treated at o…
Brain arteriovenous malformations (bAVMs) are vascular anomalies characterized by direct arterial to venous shunting without an intervening capillary bed, predisposing patients to intracranial hemorrhage and subsequent neurological morbidity and mortality. Evidence suggests that development and evolution of bAVMs are influenced by ongoing molecular and inflammatory processes. C…
Karunya A S, K. Sudeep Kumara, Avin Kumar, Kamalaksh Shenoy
Abstract Head and neck cancer (HNC), a heterogeneous group of malignancies that arising from the mucosal surfaces of the Upper Aerodigestive Tract (UADT), is a major health concern worldwide. By 2050, the number of cancer cases worldwide is expected to reach 35 million, with nearly half of all new cases and deaths occurring in Asia. In India, HNC is particularly prevalent accou…
Choroidal, optic disc and crystalline lens colobomas are rare ophthalmological conditions, but they can (either directly or by association) present with retinal detachments that are difficult to manage. Due to their rarity and variability of presentation, evidence of different approaches to treatment strategies is mainly found in case reports or small case series. This article …
Farzan Fahim, Amirmahdi Mojtahedzadeh, Farnaz Mortezazade, parvane tayebzadeh et al.
BackgroundRadiotherapy can provide durable local control for optic pathway-hypothalamic glioma (OPHG), but its use is limited by concern regarding delayed vascular, endocrine, visual, oncological, and neurological toxicities. ObjectiveTo systematically characterize and quantify the safety of radiotherapy and radiosurgery for OPHG and explore clinically relevant modifiers of tre…
William Keustermans, Seppe Sels, Thomas De Kerf, Rhys Evans et al.
Accuracy evaluation of phase-shifting profilometry as a motion management add-on for intracranial stereotactic radiosurgery, Keustermans, William, Sels, Seppe, De Kerf, Thomas, Evans, Rhys Gustaf, de Freitas Nascimento, Luana, Hrsak, Hrvoje, Dolanski Babić, Sanja, Vanlanduit, Steve
Stereotactic Radiosurgery (SRS) is the treatment of choice for patients with brain metastasis subject to NHS commissioning criteria. Upon diagnosis patients are required to inform the DVLA and to cease from driving. During the SRS consultation at least 25% of patients are unaware of this and will often say that having to give up driving is worse than a diagnosis of brain metast…
Helbert de Oliveira Manduca Palmiero, Eberval Gadelha Figueiredo
BACKGROUND: NF2-related schwannomatosis is a rare tumor-predisposition syndrome characterized by bilateral vestibular schwannomas (VS) that frequently lead to progressive hearing loss and neurological morbidity. Multi-modality strategies-microsurgery, radiosurgery, radiotherapy, systemic therapy, observation-are employed, but optimal treatment selection remains challenging due …
Shenghong Wu, Zhijun Xiao, Yu Wang, Renhua Huang et al.
To compare survival and intracranial outcomes between single- and two-fraction SRS for brain oligometastases, and to explore whether primary tumor control status and biologically effective dose (BED) are associated with outcomes. In this multicenter, retrospective, propensity score-matched (PSM) study, 280 patients treated with single-fraction (16 Gy) or two-fraction (9–14 Gy/f…
Small cell lung cancer (SCLC) remains a biologically aggressive neuroendocrine carcinoma characterized by early metastatic spread, frequent relapse, and poor long-term survival. After several decades of limited progress, recent therapeutic advances have begun to reshape management across disease stages. In limited-stage SCLC, concurrent platinum-etoposide chemoradiotherapy rema…
Poul M. Schulte-Frankenfeld, Tim Decker, Isabel Bünger, Sarah Bamberg et al.
Abstract Intrathecal antibody synthesis is a hallmark of multiple sclerosis (MS). Although some intrathecally synthesized antibodies in MS are known to target viral antigens, the spectrum of their antigenic specificities remains incompletely defined. We combined proteome-wide antibody profiling by Phage ImmunoPrecipitation Sequencing (PhIP-Seq) with cross-compartment analytics …
Lung cancer brain metastasis (LCBM) is a major cause of cancer-related mortality, driven by the restrictive blood–brain barrier (BBB), an immunosuppressive microenvironment, and dynamic metabolic reprogramming. Increasing evidence suggests that LCBM is governed by coordinated interactions among neural, immune, and vascular components that regulate metastatic colonization, progr…
Kraus LM, Goldberg M, Backhaus PS, Albrecht C et al.
BackgroundBrain metastases are associated with a poor prognosis. While systemic therapy primarily determines overall survival, surgical cytoreduction may improve local disease control. Preserving neurological function and independence is particularly important in patients with limited life expectancy. However, surgery is often avoided for metastases located in eloquent brain re…
Triple-negative breast cancer (TNBC) is a subtype of breast cancer associated with a poor prognosis; conventional treatments provide limited durable benefit, and resistance commonly develops. The introduction of immune checkpoint inhibitors (ICIs) has expanded treatment options for TNBC; however, ICI monotherapy has demonstrated limited efficacy, particularly in patients with a…
Bin-Alamer O, Haider MA, Balasubramanian K, Mittal A et al.
PurposeTransformation of vestibular schwannoma (VS) into malignant peripheral nerve sheath tumor (MPNST) is rare and poorly characterized. We have synthesized available evidence from the literature to define clinical features, transformation patterns, management strategies, and survival outcomes in patients with MPNST after histologically confirmed transformation from VS.Method…
Akkus Yildirim B, Beduk Esen CS, Yuce Sari S, Ozyar E et al.
PurposeBrain metastases (BM) are the most common intracranial malignancies. However, the lack of high-level evidence comparing single- and multi-fraction stereotactic radiotherapy (SRT) results in substantial practice variability. We aimed to assess fractionation preferences and clinical decision-making among radiation oncologists (ROs) in Turkey.Materials and methodsA 21-quest…
Muteeb G, El-Sayed AY, AboHoussien MS, Abuelnile RH et al.
Brain metastasis originating from breast cancer is an uncommon but clinically significant complication that poses substantial therapeutic challenges and is associated with poor patient prognosis. Traditional treatment modalities-including surgical resection, whole-brain radiation therapy, stereotactic radiosurgery, and systemic chemotherapy-often fail to achieve satisfactory lo…
Niitsu H, Tamaki Y, Hiroshima Y, Murakami M et al.
Advances in chemotherapy and radiotherapy have expanded indications for stereotactic radiosurgery/radiotherapy (SRS/SRT) for multiple brain metastases. We introduced the Elements Multiple Brain Mets System (mSRS/SRT system), using the dynamic conformal arc method with a single isocenter, for treatment of multiple brain metastases with SRS/SRT (mSRS/SRT). This study analyzed out…
Sandmann ACA, Verbaan D, Coutinho JM, Vandertop WP et al.
Background and objectivesThere is ongoing clinical equipoise regarding the optimal treatment strategy for symptomatic cerebral cavernous malformations (CCMs). The aim of this study was to estimate the causal effect between CCM intervention (microsurgical resection or stereotactic radiosurgery) and clinical outcomes during long-term follow-up.MethodsThis population-based cohort …
PurposeAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and repetitive, restricted behaviors or interests. The global male-to-female ratio ranges between 3:1 and 4:1, attributed to factors such as the female protective effect, extreme male brain theory, female autism phenotype, and camouflaging. Understanding g…
Ben-Mouel OS, Shemesh SZ, Dumanis G, Abofani H et al.
BackgroundChildhood scalp irradiation for tinea capitis (TC) increases the long-term risk of intracranial meningiomas. It remains unclear whether prior TC irradiation affects meningiomas' response to stereotactic radiosurgery (SRS). We compared TC-irradiated and sporadic meningiomas treated with SRS.MethodsAmong 539 meningioma patients treated with SRS from 2010-2023, 204 met c…
Peer-ReviewedPubMedClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
ObjectiveTo identify real-world prognostic indicators affecting patients with non-small cell lung cancer brain metastasis (NSCLC BM) and to develop a pragmatic nomogram for individualized survival prediction.MethodsWe collected clinical data from 590 patients with NSCLC BM treated in the department of oncology at our hospital from January 2020 to December 2023, and randomly div…
Protopapa M, Platoni K, Psarras M, Nikoloudi ST et al.
AimThe aim of our study was to evaluate the safety and efficacy of delivering systemic treatments concurrently with whole-brain radiotherapy (WBRT).MethodsA single-institution, prospective observational study was conducted in Athens, Greece, including 99 patients treated with WBRT for brain metastases from September 2017 until October 2019, and with a follow-up period extending…
Dehnavi NS, Kamroo A, Habibi MA, Mirjani MS et al.
Intracranial arteriovenous malformations (AVMs) are complex vascular lesions associated with hemorrhage, neurological morbidity, and mortality. This study evaluates the efficacy and safety of frameless stereotactic radiosurgery (SRS) for brain AVMs. A comprehensive literature search was conducted across three databases through February 8, 2026. Primary outcomes included complet…
Christodoulou R, Rahimy E, Pollom EL, Hayden Gephart M et al.
Background and purposeDifferentiating recurrent tumor from radiation necrosis after stereotactic radiosurgery remains a challenge with conventional MRI. Fractional tumor burden, a voxel-level perfusion biomarker originally developed using DSC-MRI, characterizes intralesional perfusion heterogeneity and has demonstrated good performance and improved interrater agreement in diagn…
Begagić E, Bečulić H, Harčinović AK, Huseinspahić N et al.
PurposeTriple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with a high risk of early central nervous system dissemination and poor outcomes after brain metastasis (BM). This systematic review summarizes current evidence on incidence, treatment strategies, outcomes, guidelines, and ongoing trials in TNBC-associated BM.MethodsThe review followed PRISMA gui…
PurposeCerebral sinus vein thrombosis (SVT) is a feared complication of brain tumour surgery, especially in sinus adjacent locations. In the comprehensive treatment of brain metastases (BM) intraoperative radiotherapy (IORT) is recently being established as a safe alternative to postoperative adjuvant stereotactic radiosurgery (SRS). However, uncertainty of on the risk about SV…
Stereotactic radiosurgery (SRS) is a well-established treatment for intracranial meningiomas. The optimal timing of post-treatment imaging follow-up ideally promotes early detection of clinically significant radiographic changes while minimizing resource utilization and patient distress. This study explores the patient and tumor characteristics that may impact early imaging tim…
Three-dimensional (3D) histology provides volumetric insights into tissue microarchitectures across entire specimens, holding great promise for more accurate prognostication. However, existing methods are too slow for intraoperative consultations. We present ULTRA (ultrarapid cleared stimulated Raman with AI), a label-free, stain-free, fixation-free, and section-free platform t…
Prinzi A, van Velsen EFS, Krajewska J, Kolton M et al.
BackgroundBrain metastases (BMs) from nonanaplastic follicular cell-derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features, treatment patterns, and outcomes of patients with BMs from non-ATC and to develop and validate a dise…
ImportancePublic concern and speculation have emerged around a possible link between neonatal male circumcision (NMC) and autism spectrum disorder (ASD). Evidence is limited and inconsistent.ObjectiveTo examine associations between NMC and child ASD and autism-related traits and behaviors.Design, setting, and participantsThis prospective cohort study was conducted among cohort …
IntroductionSingle-fraction stereotactic radiosurgery (SRS) is recommended for small brain metastases (MethodsWe retrospectively analyzed cumulative incidences of LTF, defined as tumor regrowth within the planning target volume, following 18 Gy single-fraction SRS (July 2014-December 2021) in patients with brain metastases. Patients with prior radiotherapy or surgery to the ind…
BackgroundBrain metastases in patients with breast cancer (BCBM) are common. While the Breast Graded Prognostic Assessment (Breast GPA) predicts overall survival (OS), its ability to predict intracranial progression-free survival (icPFS) has not been established.MethodsWe conducted a retrospective, multi-institutional cohort study to evaluate the association between Breast GPA …
Hassan GA, Hussein AFA, Saydo B, Buccilli B et al.
Despite the well-established efficacy of stereotactic radiosurgery in achieving obliteration of cerebral arteriovenous malformations (AVMs), a subset of patients, particularly those with large, deep-located AVMs, fail to achieve substantial obliteration. The CyberKnife machine offers a novel radiosurgery strategy by enhancing targeted precision and dosimetric flexibility. Herei…
IntroductionGenomic instability is common in cancer, driven by different mechanisms and often linked to disease stage and progression. Optical genome mapping (OGM) enables the detection of genome-wide balanced and unbalanced structural rearrangements (SRs), providing an overview of genomic complexity.AimsTo explore the utility of OGM in brain tumour characterisation, we conduct…
BackgroundHyperArc is an effective technique for treating multiple small brain metastases using high-definition, precise radiation. However, the small size of individual lesions makes treatment vulnerable to inherent inaccuracies from beam-limiting devices such as multi-leaf collimators (MLCs), as well as patient setup errors. These uncertainties must be thoroughly evaluated pr…
Yamamoto Y, Nakamura A, Ikemura A, Maetani T et al.
BackgroundCystic brain metastases pose a therapeutic challenge for stereotactic radiosurgery (SRS) because of their large volume. Stereotactic cyst aspiration with Ommaya reservoir placement followed by SRS has emerged as a minimally invasive strategy to facilitate effective irradiation; however, catheter-tract recurrence remains rarely reported.Case descriptionA patient with e…
ObjectiveStereotactic body radiotherapy (SBRT) for metastatic spinal disease provides effective local control (LC). However, there are limited data evaluating how the pretreatment volume or number of affected vertebral levels impacts treatment effect. Therefore, this study compared the efficacy of spine SBRT treatment on LC, distant progression (DP), and overall survival (OS) b…
Snyder-Robinson syndrome (SRS), a rare X-linked disorder caused by pathogenic variants in spermine synthase (SMS), results in spermine deficiency and excessive spermidine accumulation. Previously reported mouse models exhibited reduced birthrate and survival of affected males, greatly limiting their experimental utility. Here we describe a new mouse model carrying the clinicall…
Brain metastases (BM) in renal cell carcinoma (RCC) are associated with poor prognosis and limited clinical guidance. We aimed to identify prognostic factors for overall survival (OS) in RCC BM and develop an interpretable machine-learning (ML) model for individualized risk prediction. We retrospectively analyzed 929 patients with histologically confirmed clear cell RCC BM trea…
This exploratory study investigates the effectiveness of EEG-guided Transcranial Magnetic Stimulation (TMS) in treating children with Autism Spectrum Disorder (ASD). ASD is a neurodevelopmental disorder affecting about 1 in 36 children , with neuroimaging studies revealing brain abnormalities, particularly in the frontal and temporal lobes, along with changes in gray and white …
IntroductionBrain metastases (BM) causes significant morbidity and mortality in epidermal growth factor (EGFR) mutated non-small cell lung cancer (NSCLC). The effect of EGFR alteration subtypes on CNS-specific outcomes is poorly defined.MethodsPatients with EGFR-mutated NSCLC and BM treated with firstline osimertinib with or without SRS were retrospectively identified from 11 i…
Rezazadeh Shirazi A, Kumar JI, Dold K, Thompson GH et al.
PurposeLateral electrical surface stimulation (LESS), commercially known as the ScoliTron™, emerged in the late 1970s as a noninvasive alternative to bracing for adolescent idiopathic scoliosis. Early clinical reports generated considerable enthusiasm and adoption, but the technique was ultimately abandoned. This study examined the rise and fall of LESS through a combined analy…
Váscones-Román FF, Fuentes-Garcia SJ, Rodriguez-Aguilar NA, Carrascal-Gutiérrez RM et al.
BackgroundIntraventricular meningiomas (IVMs) are rare adult tumors in deep-seated ventricular locations with challenging surgical anatomy and heterogeneous management. Contemporary pooled benchmarks for extent of resection, complications, and recurrence in adult intraventricular meningiomas remain limited.MethodsA systematic review and meta-analysis was performed following PRI…
Abstract Background Sex-specific phenotype heterogeneity, e.g. social behaviour differences have been commonly observed in autism spectrum disorder (ASD) and pose substantial challenges for accurate diagnosis. The neural and biological basis of these differences remains unclear. Given the sex-differential brain lateralisations, we aim to examine the roles of cortical morphologi…
Autism spectrum disorder (ASD) is highly heritable; however, the neural architecture underlying semantic processing and social functioning, and the extent to which it reflects familial liability, remains insufficiently understood. Unaffected siblings (SIB), who share substantial genetic liability with individuals with ASD, offer a critical framework for identifying intermediate…
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