Per-site SBRT setup — body frame, abdominal compression, knee + ankle support reproducibility. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Kaczynska A, Jin F, Stewart M, Kipritidis J et al.
Objective.Real-time six-degree-of-freedom (6DoF) tumour motion monitoring is important for accurate stereotactic body radiotherapy (SBRT) of thoracic and abdominal cancer sites, yet existing approaches either require specialised imaging hardware or continuous fluoroscopic imaging. This study presents the development and first experimental implementation of a real-time image-gui…
Ryota Tozuka, Masahide Saito, Masaki Matsuda, T. Akita et al.
BACKGROUND: Accurate contouring of target volumes and organs at risk is critical in radiotherapy. While deep learning (DL) models offer automated contouring, their clinical applicability to real-world cases containing anatomical variations and artifacts requires rigorous validation. PURPOSE: To evaluate the clinical accuracy and potential vulnerabilities of RatoGuide, novel DL-…
BACKGROUND: Patient-Specific Quality Assurance (PSQA) for Elekta Unity MR-Linac treatments delivered under Comprehensive Motion Management (CMM) is challenging because beam gating, unexpected interruptions, and split sub-segments introduce delivery complexities that are not fully addressed by conventional quality assurance workflows. PURPOSE: This study aimed to develop and eva…
Taoran Li, Esa Kuusela, Emmi Ruokokoski, H. Hyvonen et al.
BACKGROUND: Conventional VMAT optimization largely treats delivery time and deliverability as emergent properties of simplified, control-point-centric models that often ignore finite acceleration and other dynamic limits. As modern linacs continue to increase maximum axis speeds and dose rates, there is a growing need for a planning paradigm that makes the plan quality-time tra…
Karunya A S, K. Sudeep Kumara, Avin Kumar, Kamalaksh Shenoy
Abstract Head and neck cancer (HNC), a heterogeneous group of malignancies that arising from the mucosal surfaces of the Upper Aerodigestive Tract (UADT), is a major health concern worldwide. By 2050, the number of cancer cases worldwide is expected to reach 35 million, with nearly half of all new cases and deaths occurring in Asia. In India, HNC is particularly prevalent accou…
William Keustermans, Seppe Sels, Thomas De Kerf, Rhys Evans et al.
Accuracy evaluation of phase-shifting profilometry as a motion management add-on for intracranial stereotactic radiosurgery, Keustermans, William, Sels, Seppe, De Kerf, Thomas, Evans, Rhys Gustaf, de Freitas Nascimento, Luana, Hrsak, Hrvoje, Dolanski Babić, Sanja, Vanlanduit, Steve
Significant dose variations among cervical cancer patients with similar geometric characteristics may limit the effectiveness of knowledge-based planning (KBP) techniques that rely solely on geometric features for volumetric modulated arc therapy (VMAT) planning. To address this issue, this study adapts methodologies from prior research and proposes integrating dosimetric featu…
Roberto Luigi Cazzato, Xavier Buy, Fernando Gómez, Frederic Deschamps et al.
PURPOSE: Cryoablation (CA) is a well-established, safe and effective palliative treatment for painful bone metastases (BM). Data exploring its curative potential (i.e. radical clearing of the target lesion) is however very scarce, mostly coming from small retrospective studies. The BOne metastases REgistry for patients undergoing cryoAbLation with curatIve purpoSe (BOREALIS) ai…
Abstract Forensic sketching translates a witness description into a visual representation of a suspect, but sketches often lack visual details, which can limit their use in face recognition systems. This paper presents a sketch-guided face generation pipeline based on a Conditional Variational Autoencoder (CVAE) designed to generate facial reconstructions from sketches and cond…
Francesco Cuccia, Gianluca Mortellaro, Maria Campione, Vanessa Figlia et al.
Background The use of stereotactic body radiotherapy for primary and secondary lung lesions is well established. Although being supported by international guidelines, the application of single-fraction treatments is less reported in the literature. Methods We report a mono-institutional, retrospective analysis of inoperable patients with small lung lesions—including both primar…
Annelien Boonen, Fien Verstappen, Sandra Nuyts, Paul M. Clément et al.
Background Human papillomavirus (HPV) has substantially altered the epidemiology and prognosis of oropharyngeal squamous cell carcinomas (OPSCC), with an increasing incidence in younger patients and markedly improved survival outcomes. This shift presents an increasing clinical challenge: how to safely reduce treatment intensity, while maintaining cure and survival rates and mi…
Siyang Huang, Songhua Yang, Yang Dong, Sheng Huang et al.
OBJECTIVE: This study proposes a 2π solid angle-based heuristic framework for non-coplanar volumetric modulated arc therapy (VMAT) in patients with multiple brain metastases (MBM) to automate treatment angle selection. Approach: Fifty-two patients with MBM (2-8 targets) were retrospectively included. A hybrid heuristic framework was constructed: first, a volume-weighted cumulat…
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang et al.
The abscopal effect is a systemic antitumor response to localized radiotherapy (RT) that has emerged as a central focus in the era of immunotherapy. Clinical evidence demonstrates that local RT can induce regression of distant, nonirradiated metastases, including cases of complete remission. However, the effect remains unpredictable, with marked variation in clinical outcomes r…
O. El mouden, H. Sekkat, A. Bannan, R. El Baydaoui et al.
Accurate characterization of the tissue–maximum ratio (TMR) is important for beam modelling and dosimetric verification, particularly for flattening-filter-free (FFF) beams and non-reference fields. This study characterized TMR for 6 MV flattened (FF) and FFF photon beams from an Elekta Versa HD across square fields from to . Central-axis water-phantom measurements using PTW mi…
Synergizing radiotherapy (RT) with immune checkpoint inhibitors has emerged as a promising strategy for solid tumors. RT acts as a potent immunomodulator, capable of functioning as an in situ vaccine through the induction of immunogenic cell death and activation of innate immune sensing, thereby promoting DC maturation and CD8+ T cell responses. However, RT also triggers counte…
PurposeThis study aimed to evaluate the clinical feasibility and efficacy of a novel abdominal compression airbag (ACA) for respiratory motion management and setup reproducibility in upper abdominal radiotherapy and to compare its performance against free breathing (FB) and the standard abdominal compression plate (ACP).MethodsA total of 54 patients with upper abdominal maligna…
Peer-ReviewedPubMedPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026
Daly M, Choudhury A, McWilliam A, Radhakrishna G et al.
BackgroundRespiratory motion is a challenge for accurate stereotactic ablative radiotherapy (SABR) to the liver. This study compares the dosimetric impact of abdominal compression (AC), breath hold (BH) and free-breathing (FB) strategies for liver SABR on conventional C-arm linear accelerators (Linacs) and magnetic resonance Linacs (MR Linacs).MethodsFive patients undergoing li…
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