Tangential breast IMRT, DIBH heart-sparing, prone breast and combined breast-and-nodal positioning. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Yeonseo Jang, Hyeran Kim, Yufei Li, Jae-Seung Lee et al.
Background Coronaviruses (CoVs), including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome (MERS-CoV), cause respiratory infections with distinct clinical outcomes and case fatality rates. However, the molecular basis of these differences remains unclear. In this study, we sought to define virus-specific host metabolic programs …
Citrus-derived flavonoids, particularly naringenin, hesperidin, and hesperetin, have emerged as promising bioactive compounds with potential therapeutic relevance in hepatocellular carcinoma (HCC). This review provides a focused synthesis of current preclinical evidence regarding their anticancer properties and underlying molecular mechanisms in experimental HCC models. These f…
Cancer progression is shaped not only by genetic alterations but also by dynamic remodeling of regulated cell death. MicroRNAs (miRNAs) have emerged as central regulators of these processes by coordinating gene expression, metabolic balance, and stress responses. This review summarizes current understanding of how miRNAs modulate ferroptosis, anoikis, and pyroptosis across live…
Digital tongue diagnosis has advanced considerably through image-based feature extraction and machine learning, yet its dominant analytical paradigm remains anchored in static, single-frame examination—an approach that inherently discards temporal information generated during the examination process, including stabilization dynamics, fluctuation patterns, and short-term physiol…
Yixia Zhou, Liuyin Jin, Weili Jiang, Lindan Sheng et al.
Background Adverse childhood experiences (ACEs) are increasingly recognized as important life-course determinants of chronic disease risk. However, the overall knowledge structure, research hotspots, and developmental trends in this field remain insufficiently characterized. This study aimed to systematically map the global research landscape of childhood adversity and chronic …
Accurate assessment of fetal lung maturity remains one of the most important challenges in perinatal medicine. Although advances in obstetric and neonatal care have substantially improved outcomes of preterm infants, respiratory distress syndrome (RDS) continues to be a major cause of neonatal morbidity worldwide. The ability to identify fetuses at risk for surfactant deficienc…
Yingjian Wang, Zhe Wang, Fangdi Zhou, Yu Qiao et al.
Gastrointestinal cancers frequently develop immune exclusion and therapeutic resistance, yet these phenotypes are often described separately. Cancer-associated fibroblasts (CAFs) are key stromal architects of immune-excluded tumor microenvironments, and their heterogeneous states can evolve under chemotherapy, radiotherapy, immunotherapy, targeted therapy, and anti-angiogenic p…
Diabetes mellitus (DM) is a systemic metabolic disorder characterized by chronic hyperglycemia, which can affect the kidneys, retina, peripheral nerves, and cardiovascular system, ultimately leading to multiple chronic complications. Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor activated through canonical cleavage, such as thrombin-mediated cleavage, and…
Marta Kamińska, Maja Chrobak, Lucas Sathler Alves Silva, Yasmin Gurtler Pinheiro de Oliveira et al.
Abstract We assessed cross-sectional relationships of rheumatoid arthritis (RA) disease activity and cardio-metabolic comorbidities with serum peptidylarginine deiminase 4 (PAD4)-potentiating activity, domain-resolved angiotensin I converting enzyme (ACE1) enzymatic activity, and Porphyromonas gingivalis -specific antibodies. 177 RA patients and 147 healthy controls (HC) were i…
Jinmin Shi, Shaimaa Abdel-Ghany, Mariam Abdel-Fattah, Xuebo Hu et al.
Adipose tissue, once considered a passive fuel store, is now recognized as a dynamic endocrine organ that shapes cancer behavior. Within the tumor microenvironment (TME), cancer-associated adipocytes (CAAs) undergo marked reprogramming-losing large lipid droplets, adopting fibroblast-like features, and intensifying lipolysis-while releasing proinflammatory mediators that accele…
This study reports the green synthesis of silver nanoparticles (PV-Ag NPs) using a pigment-producing environmental fungus, Penicillium verrucosum (PV) RPF011, as a biological reducing and stabilizing agent. The formation of nanoparticles was initially evidenced by a distinct color change from light to dark brown, corresponding to the reduction of Ag⁺ ions, and was further confi…
Chetna Mathur, Evan T. Davis, Dylan Ehrbar, Humphrey Chukwudi Omeoga et al.
Oncogenes and tumor-suppressor genes play opposing roles in cancer biology to promote and restrict growth, respectively. Codon usage patterns interface with tRNA modifications to control translation, leading to gene-specific codon signatures with regulatory potential. As such, codon-biased translational regulation has been identified as a driver of proliferation and drug resist…
Ani Harutyunyan, Jemma Manoyan, Anush Aghajanyan, Liana Gabrielyan et al.
Green algae have emerged as promising platform for the eco-friendly biosynthesis of nanoparticles owing to their abundance in proteins, pigments, polysaccharides, phenolic compounds, and other bioactive metabolites. The present study aimed to synthesize silver nanoparticles (Pk-AgNPs) using the biomass of the green alga Parachlorella kessleri MDC6524 cultivated on brewery produ…
Kiana Mokhtari, Roya Bishehkolaei, Fatemeh Peyravii Ghadikolaii, Abbas Ali Dehpour et al.
Lipopolysaccharide (LPS)-induced endotoxemia promotes systemic inflammation, oxidative stress, endothelial dysfunction, and hepatic injury. Endothelial progenitor cells (EPCs) may support vascular repair and immunomodulation, whereas surfactin, a cyclic lipopeptide derived from Bacillus subtilis , has reported anti-inflammatory and antioxidant properties. This study evaluated t…
Tuberculosis (TB) is still a major global health threat, worsened by the advancement of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis ( Mtb ). Autophagy is a natural degradation and immune process that plays a critical role in the defence against intracellular pathogens, including Mtb . However, Mtb has developed complex mechanisms to …
Computational methods play a significant role in understanding the interaction between HCMV-encoded miRNAs with their targets. MicroRNAs have a regulatory role in post-transcriptional gene expression thereby resulting in translational repression or mRNA degradation. The Human Cytomegalovirus, a Herpesviridae family encodes their own collection of miRNAs which help to modulate t…
Low-dose computed tomography (LDCT) is an effective screening tool for early lung cancer detection; however, it frequently reveals incidental findings (IFs) beyond suspicious pulmonary nodules. We conducted a multicenter observational analysis using data from a community-based, non-risk-stratified mobile LDCT screening program implemented across ten screening regions in China b…
Puspamitra Panigrahi, Kulothungan Balasundaram, Yash Pal, Mukesh K. Choudhary et al.
Cardiovascular disease is a leading cause of global mortality, driving the need for non-invasive early detection methods. Analysis of specific volatile organic compounds (VOCs) in exhaled breath, such as acetone, hexane, hexanal, isoprene, and pentane, offers a promising diagnostic pathway. However, the selective detection of these low-concentration VOC biomarkers remains a sig…
Tomoko Nomiyama, Daiki Setoyama, Ikumi Yamanaka, Masatoshi Shimo et al.
Pre-infusion cerebrospinal fluid (CSF) proteomics may enable risk stratification for immune effector cell-associated neurotoxicity syndrome (ICANS) after chimeric antigen receptor T-cell therapy, but disease-specific baseline variation may influence biomarker interpretation. We compared pre-infusion CSF proteomic profiles from 28 patients with diffuse large B-cell lymphoma (DLB…
Triazole-based hybrids have evolved into important pharmacophores in the search for anticancer drugs because of their varied biological profiles and structural adaptability. The versatility of triazole scaffolds in forming hybrid molecules with other compounds such as pyridines, coumarins, chalcones, pyrimidines, indoles, etc., has expanded the range of potential anticancer com…
Maria Garcia Requesens, Arun K. Mankan, Luca Cantini, Marco Calabresi et al.
Health Digital Twins (HDTs) have attracted increasing interest as a potential tool for improving both patient care and clinical research, particularly in oncology where clinical trials remain slow, costly, and operationally complex. This primer introduces the concept of digital twins in a form accessible to professionals involved in oncology clinical research and outlines the m…
Short-form video platforms have become a major component of the pre-consultation information environment for patients with cancer in China and may create new challenges for clinical communication. Contemporary shared decision-making (SDM) and patient decision aids (PtDAs) do not explicitly assess or calibrate beliefs formed before consultation. Algorithmic recommendation and em…
Seung-Hyeop Baek, Keith M. Furutani, Seyjoon Park, Justin C. Park et al.
Purpose: We aimed to evaluate the feasibility of using a horizontal port (HP) system for carbon ion radiotherapy (CIRT) in non-small cell lung cancer (NSCLC) by comparing the dosimetric characteristics and dose-averaged linear energy transfer (LETd) with those of a gantry-based plan. Materials and Methods: Five patients with NSCLC treated with CIRT were included in this study. …
Transperineal mpMRI–TRUS fusion biopsy is accurate but requires multiple perineal punctures, increasing pain and complications. The coaxial needle technique reduces these burdens in systematic biopsy, but its use in fusion targeted biopsy is unreported. This study assesses the benefits of employing a coaxial needle technique with real-time virtual magnetic navigation in transpe…
Parkinson’s disease (PD) is characterized by progressive nigrostriatal degeneration, yet the contribution of modification-rich small RNAs to PD pathology remains unclear. Here, we used PANDORA-seq to profile the striatal small RNA landscape in a subacute MPTP-induced mouse model of PD. MPTP-treated mice exhibited significant motor deficits together with reduced striatal tyrosin…
Robert Figlin, Kate O’Shaughnessy, Setu Shah, Chad Giese et al.
Background Health systems face increasing oncology demand amid workforce constraints and rising care complexity. Outpatient cancer volumes in the United States are projected to grow nearly 18% over the next decade, driven by earlier diagnoses, evolving screening guidelines, and continued site-of-care shifts — while inpatient volumes remain essentially flat but grow in case mix …
Cahit Kaya, Kanako Iwanaga, Fong Chan, Elif Gökçearslan et al.
Purpose/Objective: The aim of this study was to examine the factor structure of the functional subscale items of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) among Turkish cancer patients and its associations with perceived stress and community participation. Research Method/Design: A total of 186 Turkish cancer pa…
Abstract A highly consistent image quality assessment method that integrates human visual mechanisms and multimodal perceptual features is built to enhance its sensitivity to complex distortions such as structural degradation, color shift, and phase perturbation. The limitations of traditional pixel-difference-dependent metrics in representing human perception and exhibiting li…
Shrijee Lakshkar, Pratha Tiwari, Heenal Bhatt, Vipin Ranga et al.
Prostate cancer is a major global health burden. According to GLOBOCAN 2022 estimates, it accounts for nearly 396,792 deaths and 1,466,680 cases annually. Despite advances in immunotherapy, hormone therapy, radiation, chemotherapy, and surgery, improved biomarkers for early detection and targeted treatment remain urgently needed. In this study, cancer genomics data from cBioPor…
Background: The metabolic characteristics of preterm infants in the early postnatal period are closely linked to their growth and development. Investigating the corresponding metabolic changes that occur during the early postnatal maturation process of preterm infants may help improve their clinical management. In this prospective cohort study, we aimed to characterize urinary …
Óscar Arias-Carrión, Magdalena Guerra‐Crespo, Luis O. Soto-Rojas, Yeminia Valle et al.
Parkinson’s disease (PD) is traditionally described as a dopaminergic neurodegenerative disorder driven by α-synuclein aggregation and selective neuronal loss in the substantia nigra pars compacta. While this characterization captures the core clinical and pathological features, it does not fully explain disease initiation and progression. Converging evidence from human genetic…
Purpose— Augmented Reality (AR) is a novel cutting-edge technology that is increasingly being employed by various surgical fields for navigation, including orthopedic surgery. In our pre-clinical studies, we implemented AR in two key domains of orthopedic surgery, i.e., orthopedic oncology and total hip arthroplasty (THA), for surgical guidance and to assess its accuracy and fe…
Giulia Pagani, Chiara Casirati, Cecilia Pandini, Stefania Fornezza et al.
Abstract Background Alternative polyadenylation (APA) is increasingly recognized as a pervasive oncogenic mechanism that reshapes post-transcriptional gene regulation and promotes tumor aggressiveness. Whether APA contributes to the dysregulation of NFYA —encoding the regulatory subunit of the oncogenic transcription factor NF-Y—in prostate cancer (PCa) remains largely uncharac…
Lihui Liu, Honglin Chen, Jingxiao Wang, Jingjing Yang et al.
Most patients with cancer are older adults living with several other chronic illnesses, and both the tumour and its commonest companions—cardiometabolic disease, type 2 diabetes and depression—are sustained by a shared, immunosuppressive inflammatory milieu. In this setting many tumours are immunologically “cold”: poorly infiltrated by cytotoxic T and natural killer (NK) cells,…
Howyn Tang, Gary Sun, Chao Lu, Hossein Pouri et al.
Early and accurate identification of disease-associated biomarkers is essential for timely diagnosis and the advancement of personalized healthcare. Although blood and cerebrospinal fluid remain the clinical gold standards, increasing attention is being directed toward non-invasive biofluids, such as urine, saliva, tears, and sweat. as accessible and patient-friendly alternativ…
Yahui Zhao, Ruixiang Zhang, Yang Li, Yang Li et al.
Immune checkpoint inhibitor (ICI) responses in esophageal squamous cell carcinoma (ESCC) are highly variable, and the immune mechanisms underlying therapeutic sensitivity remain unclear. Here we show, using single-cell RNA, T-cell receptor and whole-exome sequencing of 52 ESCC patients from a phase 3 neoadjuvant trial, that treatment response is associated with coordinated tumo…
Giorgia Moranzoni, Lasse Vedel Jørgensen, Javier Herranz del Cerro, Antoine Andréoletti et al.
Chimeric antigen receptor (CAR) cell therapy has achieved transformative clinical success through targeting of CD19 in refractory B cell malignancies, but extension of this strategy to solid tumors, other hematological malignancies, and autoimmune disease has exposed the complexity of target selection. Antigen abundance alone is not sufficient to define a suitable CAR target. I…
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng et al.
Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs), or alarmins. Traditionally, PAMPs and DAMPs were catego…
Hengyu Wu, Ganghua Yang, Yuanzheng Zhu, Yanglong Zhu et al.
Abstract Background Autologous fat grafting is widely used in reconstructive and aesthetic surgery, but its clinical outcomes are limited by early ischaemia–hypoxia, oxidative stress, delayed vascularization, and subsequent lipid accumulation-induced inflammation. Current therapeutic strategies generally focus on single-stage regulation and lack temporal coordination with the d…
Eslam E. Abd El-Fattah, G. Ngai, Rachael Mooney, Karen S. Aboody
PURPOSE OF REVIEW: Obesity is a potent risk factor for cancer, primarily driven by a state of chronic inflammation. A key mechanism linking adipose tissue dysfunction to tumorigenesis is the induction of cellular senescence and the related Senescence-Associated Secretory Phenotype (SASP), which is not clearly defined. RECENT FINDINGS: In obesity, expanding adipose tissue become…
Interstitial photothermal therapy (IPTT) enhanced with indocyanine green (ICG) represents a minimally invasive approach with growing interest for localized thermal ablation of deep-seated tumors. In this work, an optical–thermal modeling framework is developed to investigate heat generation, transfer, and thermal damage during ICG-assisted IPTT using cylindrical diffuser fibers…
Karunya A S, K. Sudeep Kumara, Avin Kumar, Kamalaksh Shenoy
Abstract Head and neck cancer (HNC), a heterogeneous group of malignancies that arising from the mucosal surfaces of the Upper Aerodigestive Tract (UADT), is a major health concern worldwide. By 2050, the number of cancer cases worldwide is expected to reach 35 million, with nearly half of all new cases and deaths occurring in Asia. In India, HNC is particularly prevalent accou…
Xuecong Wang, Cecilia Xi Zhang, Yi Zhao, Jianxing He et al.
Epithelial–mesenchymal transition (EMT), historically described as a binary morphological change from an epithelium to a mesenchymal state, no longer adequately accounts for carcinoma cell phenotypes observed in patients. Single-cell sequencing, spatial-omics, and lineage tracing converge on a different picture as carcinoma cells rarely undergo a unidirectional transition endin…
Charlène Clot, Rénald Delanoue, Laura Helena Lavocat, Sélia Namouchi et al.
Abstract Sex differences in cancers arising in non-reproductive organs are widespread. While sex hormones and the intrinsic sexual identity of cancer cells are well-established contributors, it is unknown whether other mechanisms are involved. Here, we reveal an unexpected source of sex-biased cancer vulnerability in a Drosophila model of tumorigenesis. By combining genetically…
BACKGROUND: Reliable prognostic biomarkers are urgently needed for operable esophageal squamous cell carcinoma (ESCC), as conventional histopathology often fails to detect minimal residual disease and accurately predict patient outcomes. PATIENTS AND METHODS: This study investigated the mutational patterns in ESCC and the prognostic value of shared mutations between tumors and …
The rapid adoption of Generative Artificial Intelligence (GenAI) has accelerated digital innovation across diverse sectors; however, challenges such as hallucination, limited transparency, and insufficient reasoning traceability continue to restrict its deployment in high-stakes applications. This study proposes a Case-Based Explainable Generative Artificial Intelligence (CB-XG…
Background: Immigrant patients with limited dominant-language proficiency may face intersecting challenges when navigating cancer care and long-term oral anticancer treatment. Although studies have reported lower medication adherence among migrant and ethnic minority populations, less is known about how migration-related, linguistic, experiential and contextual factors shape tr…
Jiexia Wen, Yunhuan Gao, Meimei Xu, Muran Li et al.
The gut microbiota and natural killer (NK) cells jointly shape colorectal cancer (CRC) progression and immunotherapy response, yet existing reviews largely adopt a linear, pathogen-centric view that overlooks NK-cell heterogeneity and spatial tumor microenvironment architecture. We propose an integrated framework centered on three progressive pillars: (i) the microbiota appears…
Suqin Wang, Aftab Shaukat, Mohammed Al-Rasheed, Abdul Malik Tareen et al.
Milk-derived extracellular-vesicles (mEVs) have emerged as a promising natural nanocarriers for nutraceutical and therapeutic applications, owing to their rich cargo of bioactive proteins, lipids, microRNAs, and metabolites, coupled with their inherent biocompatibility and stability. Their unique ability to withstand gastrointestinal degradation and cross biological barriers, s…
Death anxiety is associated with adverse psychological and health outcomes, yet findings regarding the role of religiosity and spirituality (R/S) as protective or risk factors remain mixed. Prior research has relied on convenience samples, combined disparate R/S constructs, and rarely tested nonlinear associations. This study examined associations between death anxiety and mult…
Tell us who you are and we’ll send the full product brochure to your institutional email after a quick review. We respond within one working day (Mon–Fri, 9:30–18:30 IST).
Request received
A Saxsons sales engineer will review your request and send the brochure to your institutional email within one working day. You may receive a verification call before processing.
